Long-Term Melatonin Use Linked to Increased Heart Risks
Using melatonin supplements for sleep problems over a long period may carry unexpected dangers for heart health. Researchers observed that chronic users had nearly double the risk of death and were 3.5 times more likely to be hospitalized for heart failure.
Study Findings Presented at AHA 2025
A preliminary study presented at the American Heart Association's Scientific Sessions 2025 highlighted these concerns. Adults suffering from chronic insomnia who took melatonin for a year or more showed a higher chance of developing heart failure, requiring hospitalization for it, and increased risk of death from any cause compared to non-users.
The study will be discussed at the AHA's annual meeting, held November 7-10 in New Orleans, a premier event for cardiovascular science and clinical research updates.
What Is Melatonin?
Melatonin is a hormone naturally produced by the pineal gland, managing the body’s sleep-wake cycle with higher levels produced at night and lower during the day. Synthetic melatonin supplements, identical to the natural hormone, are commonly used to treat insomnia and jet lag.
Regulatory Status and Usage
In many countries, including the U.S., melatonin can be bought over the counter without a prescription. However, its supplements are not regulated in the U.S., which can lead to significant variations in purity and dosage across products.
Expert Advice
Despite widespread belief in melatonin’s safety, medical experts now recommend caution when using it for extended periods due to potential heart-related risks.
Author's summary: Long-term melatonin use, common for sleep issues, may significantly increase heart failure risks, urging careful evaluation before prolonged use.
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