NFL Picks and Predictions for Week 6
The NFL season continues with Week 6, and here are three plus-money bets to consider.
By Spenser Davis, Published: Oct 12, 2025 · 8:30 AM EDT
Week 6 Predictions
Last week's NFL bold predictions went 2-1, resulting in a +1.17 unit overall. Since Week 3, picks in this story are up 2.16 units.
This Week's Picks
- Fading the Colts offense, despite their current average of 3.39 points per drive, which would be the highest this century if maintained all season.
Indianapolis is currently averaging 3.39 points per drive. That would be by far the most this century if the Colts are able to keep up this pace all season long.
Author's summary: NFL Week 6 plus-money bets and predictions.