Innovative Lab-Grown Liver Model Enables Advanced Study of Fibrosis and Regeneration
Researchers at the Institute of Science Tokyo have developed a sophisticated miniature liver model using human induced pluripotent stem cells (iPSCs), paving the way for a deeper understanding of liver disease progression and potential therapeutic interventions.
This three-dimensional organoid system closely mimics the interactions between essential liver cells, specifically hepatocytes and hepatic stellate cells, which play pivotal roles in liver repair and fibrotic processes.
Chronic liver disease remains a significant health concern worldwide, with millions affected by conditions that can ultimately lead to irreversible liver scarring, cirrhosis, and organ failure.
Author summary: Innovative liver model for disease study.
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